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      <JournalTitle>Journal of International Medical Research and Health Sciences</JournalTitle>
      <Volume-Issue>Volume 1 Issue 2</Volume-Issue>
      <Season>(Jul-Sept, 2021)</Season>
      <ArticleType>Health &amp; Social Care</ArticleType>
      <ArticleTitle>Water Content in Food Drink and IL-10 Level</ArticleTitle>
      <Abstract>Introduction: Water affects IL-10 levels in the body. Many people do not understand that water is very important and needed by the body for influencing IL-10 levels. The purpose of writing this paper is to be able to understand the importance of water for the body on IL-10 levels in order to avoid various conditions that interfere with health. Method: Review study. Results: The simplest but most important source of nutrients is water. The water content in the body is about 60-70%, and a loss of about 10% of the water will cause death. Water balance is obtained through food, drink, and the body__ampersandsign#39;s metabolic processes. Various components of food and beverages consumed such as coffee drinks, vegetable soups/fruit juices contain water and affect IL-10 levels in the body. Likewise, the water content in bath water and various other daily activities affect IL-10 levels in the body. Discussion: Vegetables, even drinks such as coffee contain water so that they can fulfill the body__ampersandsign#39;s health functions, both for skin health, all body organs and body tissues and cells, as well as for metabolic functions and avoiding dehydration conditions. The water content in the food we drink and the water we use greatly affects the condition of the body so that it also affects the body__ampersandsign#39;s immune response. This is related to the presence of IL-10 levels where the increase and decrease in IL-10 levels are strongly influenced by the components of the food or drink contained in the water or the water content contained in the food and drink. In fact, bathwater containing sulfur also affects IL-10 levels. So water plays an important role in IL-10 levels in the body. Conclusions: Body health is influenced by water and water also affect IL-10 levels in the body so that it is beneficial for body health related to the immune system.</Abstract>
      <Keywords>Health, Fluid, Water, Food, Drink, Interleukin 10</Keywords>
        <Abstract>https://jimrhs.com/ubijournal-v1copy/journals/abstract.php?article_id=13528&amp;title=Water Content in Food Drink and IL-10 Level</Abstract>
        <References>[1] Amy B. Understanding Food Principles and Preparation. 5th Ed. Chapter 3 Chemistry of Food Composition. Publisher Belmont, CA: Thomson/Wadsworth.(2008) page 32-3. ISBN 0-495-11910-5 978-0-495-11910-4.&#13;
[2] Popkin BM, D’Anci KE, Rosenberg IH. Water, Hydration and Health. Nutr Rev. (2010) 68(8): 439–58. 10.1111/j.1753-4887.2010.00304.x&#13;
[3] Rumiyati R, Sismindari S, Endang S, Sitarina W, Dewi TS, Brilliant KA, et . Cytoprotective activity of carrot and tomato callus extracts and the ex-pressionof cytokines in UVirradiated fibroblast cells. Indonesian Journal of Biotechnology (2019) 24(2). 10.22146/ijbiotech.51734&#13;
[4] Andersen V, Egeberg R, Tjonneland A, Vogel U. Interaction between IL-10 polymorphisms and dietary fibre in relation to risk of colorectal cancer in a Danish case cohort study. BMC Cancer. (2012); 12:183. 10.1186/1471-2407- 12-183&#13;
[5] Hazewindus M, Haenen GRMM, Weseler AR, Bast A. Protection against Chemotaxis in the Anti-Inflammatory Effect of Bioactives from Tomato Ketchup. PLoS One.(2014) 9 (12):e114387. 10.1371/journal.pone.0114387.&#13;
[6] Palozza P, Parrone N, Simone RE, Catalano A (2010).Lycopene in atherosclerosis prevention: an integrated scheme of the potential mechanisms of action from cell culture studies. Arch Biochem Biophys. (2010) 504 (1):26-33. 10.1016/j.abb.2010.06.031 (PubMed) (Google Scholar).&#13;
[7] Palozza P, Parrone N, Simone R,Catalano A (2011). Role of lycopene in the control of ROS mediated cell growth: implications in cancer prevention. Curr Med Chem (2011); 18(12):1846-60. 10.2174/092986711795496845 (PubMed) (Google Scholar).&#13;
[8] Hayden MS, West AP, Ghosh S.NF-kappaB and the immune response. Oncogene.(2006);25(51):6758- 80.10.1038/sj.onc1209943.(PubMed)(Google Scholar).&#13;
[9] Christman JW, Blackwell TS, Juurlink BH. Redox regulation of nuclear factor kappa B: therapeutic potential for attenuating inflammatory responses. Brain Pathol. (2000) 10:153-62.10.1111/j.1750-3639.2000.tb00252.x(PubMed) (Google Scholar)&#13;
[10] Frusciante L, Carli P, Ercolano MR, Pernice R,Di Mateo A, et al.Antioxidant nutritional quality of tomato. Mol Nutr Food Res. (2007); 51(5):609-17. 10.1002/mnfr.200600158 (PubMed)(Google Scholar).&#13;
[11] Rosa Lelyana. Effect of Coffee Daily Consumption for Uric Acid Level and Body Weight to Prevent Metabolic Syndrome. J Journal of Nanomedicine and Nanotechnology (2016) 7 (5).400. 10.4172/2157-7439.1000400.&#13;
[12] Lelyana R (2020) The Effect of 2 Cup Daily Coffee Consumption on the IL-10 Levels of Obese and Non Obese Male Wistar Rats. J Nanomed Nanotech Nanomat. 1: 102.&#13;
[13] Fickenscher H, Hor S, Kupers H, Knappe A, Wittmann S, Sticht H. The interleukin -10 family of cytokines: Review study .Trends Immunol.2002;23(2):89-96. 10.1016/s1471-4906(01)02149-4.&#13;
[14] Wang H, Wang L, Chi PD, Wang Wd, Chen Xq , Geng Qr, Xia Xj and; Lu Y . High level of interleukin-10 in serum predicts poor prognosis in multiple myeloma. Br J Cancer. 2016; 114(4): 463–468. 10.1038/bjc.2016.11&#13;
[15] Holland G, Zlotnik A.Interleukin-10 and cancer. Cancer Invest.1993; 11(6): 751–8. 10.3109/07357909309046950.&#13;
[16] Palma L, Marques LT, Bujan J, and Rodrigues LM. Dietary water affects human skin hydration and biomechanics. Clin Cosmet Investig Dermatol. 2015; 8: 413–21. Published 2015 Aug 3. 10.2147/CCID.S86822.&#13;
[17] Ritz P, Berrut G. The importance of good hydration for day-to-day health. Nutr Rev. 2005; 63(6 Pt 2):S6–S13. 10.1111/j.1753-4887.2005.tb00155.x.&#13;
[18] Asadullah K, Sterry W, Volk HD. Interleukin-10 and Psoriasis .In: Madame Curie Bioscience Database (Internet). Austin (TX): Landes Bioscience; 2000-2013.&#13;
[19] Prandelli C, Parola C, BuizzaL, DelBarba A. Marziano M, Salvi V, et al. Sulphurous Thermal Water Increases the Release of the Anti-Inflammatory Cytokine IL-10 and Modulates Antioxidant Enzyme Activity. Article (PDF Available) in International journal of Immunopathology and Pharmacology. 2013; 26(3):633-46. 10.1177/039463201302600307&#13;
[20] Schand;uuml;lke S. Induction of Interleukin-10 Producing Dendritic Cells As a Tool to Suppress Allergen-Specific T Helper 2 Responses. Front Immunol. 2018; 9: 455. Published 2018 Mar 19. 10.3389/fimmu.2018.00455.&#13;
[21] Ignacio RM, Kwak HS, Yun YU, Sajo MEJV, Yoon YS, Kim CS, et al. The Drinking Effect of Hydrogen Water on Atopic Dermatitis Induced by Dermatophagoides farinae Allergen in NC/Nga Mice. Evid Based Complement Alternat Med. 2013; 2013:538673. 10.1155/2013/538673.&#13;
[22] Bottin JH, Morin C, Guelinckx I, Perrier ET. Hydration in Children: What Do We Know and Why Does it Matter?.Ann Nutr Metab.2019;74(suppl 3):11-8. 10.1159/000500340.&#13;
[23] Illyas EII, Bardosono S, Surapsari J, Freisleben HJ. Effects of Electrolite Beverage on Preventing Dehydration among Workers in Different Environmental Temperature. World Nutrition Journal. 2018; 1 (2). Worldnutrijournal.org 10.25220/WNJ.V01i2&#13;
[24] Barry M.Popkin, Kristen E.D’Anci, Irwin H. Rosenberg. Water, Hydration and Health. Nutrition Reviews.www.ncbi.nlm.nih.gov.&#13;
[25] Ida S. Svendsen, Sophie C Killer, Michael Gleeson. Influence of Hydration Status on Changes in Plasma Cortisol, Leukocytes, and Antigen-Stimulated Cytokine Production by Whole Blood Culture following prolonged exercise. International Scholarly Research Notices Hindawi. 2014; p.1-10.https://doi.org/10.1155/2014/561401.&#13;
[26] MF Bergeron, JL Waler, EL Marinik (2006) Volintary fluid intake and core temperature responses in asolescent tennis players: sports beverage versus water. Br J Sports Med. 2006; 40(5): 406–10. www.ncbi.nlm.nih.gov doi: 10.1136/bjsm.2005.023333.&#13;
[27] Body temperature regulation.Nestle Waters.www.nestle-waters.com.&#13;
[28] Nisha Charkoudian, Robert W. Kenedick, Anthony J Lapadula,Albert J Swiston, Tajesh Patel, Laurie A.Blanchard, et al.(2016)Planning Military Drinking Water Needs: Development of a User-Friendly Smart Device Application. Military Medicine, 181, 9:1142. Downloaded from https://academic.oup.com/milmed/articleabstract/181/9/1142/4159826 by Rosa Lelyana on 27 July 2020&#13;
[29] Kenefick RW,Cheuvront SN, Palombo LJ, Ely BR, Sawka MN. Skin temperature modifies the impact of hypohydration on aerobic performance. J Appl Physiol. 2010; 109:79-86. 10.1152/japplphysiol.00135.2010.&#13;
[30] T Cartmell, C Ball, AF Bristow, D Mitchell, S Poole. Endogenous interleukin-10 is required for the defervescence of fever evoked by local lipopolysaccharide-induced and Staphylococcus aureus-induced inflammation in rats. J Physiol. (2003)Jun 1;549(Pt 2) : 653-64 .Published online 2003 Apr 11. 10.1113/ jphysiol.2002.037291 www.ncbi.nlm.nih.gov&#13;
[31] Takamasa Hashizaki, Yukihide Nishimura, Kenzo Teramura, Yasunori Umemoto, Manabu Shibasaki, CA Leicht, et al. Differences in serum IL-6 response after 1 °C rise in core body temperature in individuals with spinal cord injury and cervical spinal cord injury during local heat stress. Int J of Hyperthermia. (2018); 35 (1). p 541-7.&#13;
[32] Lisa R Leon, Wieslaw Kozak, Karin Rudolph, Matt J Kluger.An antipyretic role for interleukin-10 in LPS fever in mice.The American J of Physiol.1999; 276 (1 Pt2):R81-9.&#13;
[33] Warren E Rose, Jens C Eickhoff, Sanjay K Shukla, Madhulatha Pantrangi, Suzan Rooijakkers, Sara E Cosgrove, et al. Elevated serum interleukin-10 at time of hospital admission is predictive of mortality in patients with Staphylococcus aureus bacteremia. J Infect Dis. (2012); 206(10):1604-11. 10.1093/infdis/jis552.Epub 2012 Sep 10.&#13;
[34] Rosa Lelyana Soebowo.(2020). Dissertation: Coffee Consumption as Antiobesity. Selinus University, Italia. 1:33-50.</References>